Gene information
Official symbol NRG1
Official full name neuregulin 1
Gene type protein-coding gene
Chromosome8p12
Alias symbolHRG; NDF; GGF
Previous symbolHGL; NRG1-IT2
Gene familyI-set domain containing; Neuregulins
Resources
Entrez Gene 3084
HGNC HGNC:7997
Ensembl ENSG00000157168
Vega OTTHUMG00000163918
UCSC uc064luk.1
GO terms: 106 records
GO Description Category LogP Number of genes Detail
GO:0000902 cell morphogenesis GO Biological Processes -11.5134430 38 More
GO:0003007 heart morphogenesis GO Biological Processes -18.8519524 49 More
GO:0003157 endocardium development GO Biological Processes -6.82460421 7 More
GO:0003158 endothelium development GO Biological Processes -13.1102461 25 More
GO:0003161 cardiac conduction system development GO Biological Processes -7.69659659 12 More
GO:0003205 cardiac chamber development GO Biological Processes -16.2154327 37 More
GO:0003206 cardiac chamber morphogenesis GO Biological Processes -17.7982686 34 More
GO:0003208 cardiac ventricle morphogenesis GO Biological Processes -12.9810396 22 More
GO:0003229 ventricular cardiac muscle tissue development GO Biological Processes -12.2262922 19 More
GO:0003231 cardiac ventricle development GO Biological Processes -15.0525208 31 More
GO:0003348 cardiac endothelial cell differentiation GO Biological Processes -6.12313579 5 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007272 ensheathment of neurons GO Biological Processes -4.19306733 15 More
GO:0007416 synapse assembly GO Biological Processes -2.37502879 6 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007422 peripheral nervous system development GO Biological Processes -2.97285105 6 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007517 muscle organ development GO Biological Processes -15.8908392 49 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007626 locomotory behavior GO Biological Processes -5.45844211 23 More
GO:0008366 axon ensheathment GO Biological Processes -4.19306733 15 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010001 glial cell differentiation GO Biological Processes -13.0211768 33 More
GO:0014032 neural crest cell development GO Biological Processes -11.9399165 15 More
GO:0014033 neural crest cell differentiation GO Biological Processes -12.2997127 24 More
GO:0014037 Schwann cell differentiation GO Biological Processes -2.44461756 6 More
GO:0014044 Schwann cell development GO Biological Processes -2.78961389 6 More
GO:0014706 striated muscle tissue development GO Biological Processes -21.0654252 44 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0021537 telencephalon development GO Biological Processes -6.21909725 29 More
GO:0021782 glial cell development GO Biological Processes -9.97103962 23 More
GO:0021885 forebrain cell migration GO Biological Processes -5.92071483 13 More
GO:0022011 myelination in peripheral nervous system GO Biological Processes -3.03394175 6 More
GO:0022029 telencephalon cell migration GO Biological Processes -5.36863544 12 More
GO:0030296 protein tyrosine kinase activator activity GO Molecular Functions -2.46582511 5 More
GO:0030424 axon GO Cellular Components -6.14132550 54 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0030900 forebrain development GO Biological Processes -11.1545964 48 More
GO:0030971 receptor tyrosine kinase binding GO Molecular Functions -4.12949610 12 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0032148 activation of protein kinase B activity GO Biological Processes -8.71311579 12 More
GO:0032292 peripheral nervous system axon ensheathment GO Biological Processes -3.03394175 6 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034329 cell junction assembly GO Biological Processes -3.18336526 12 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0035051 cardiocyte differentiation GO Biological Processes -18.7205561 33 More
GO:0038127 ERBB signaling pathway GO Biological Processes -2.50267494 8 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0042063 gliogenesis GO Biological Processes -20.3412228 47 More
GO:0042552 myelination GO Biological Processes -4.28583448 15 More
GO:0042692 muscle cell differentiation GO Biological Processes -15.1559811 45 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045165 cell fate commitment GO Biological Processes -15.5778047 44 More
GO:0045445 myoblast differentiation GO Biological Processes -2.24389415 5 More
GO:0045446 endothelial cell differentiation GO Biological Processes -10.3072059 20 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0046578 regulation of Ras protein signal transduction GO Biological Processes -3.44587232 19 More
GO:0046579 positive regulation of Ras protein signal transduction GO Biological Processes -5.05172294 12 More
GO:0048644 muscle organ morphogenesis GO Biological Processes -13.8992054 24 More
GO:0048709 oligodendrocyte differentiation GO Biological Processes -4.76121883 12 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048738 cardiac muscle tissue development GO Biological Processes -21.5979622 44 More
GO:0048762 mesenchymal cell differentiation GO Biological Processes -16.1250183 37 More
GO:0048863 stem cell differentiation GO Biological Processes -16.2106470 36 More
GO:0048864 stem cell development GO Biological Processes -12.7283120 16 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051048 negative regulation of secretion GO Biological Processes -20.2278199 42 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051056 regulation of small GTPase mediated signal transduction GO Biological Processes -3.71798673 14 More
GO:0051057 positive regulation of small GTPase mediated signal transduction GO Biological Processes -4.49369376 12 More
GO:0051146 striated muscle cell differentiation GO Biological Processes -10.9431474 33 More
GO:0051153 regulation of striated muscle cell differentiation GO Biological Processes -11.0877013 23 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0055007 cardiac muscle cell differentiation GO Biological Processes -10.4553674 21 More
GO:0055008 cardiac muscle tissue morphogenesis GO Biological Processes -12.6682372 20 More
GO:0055010 ventricular cardiac muscle tissue morphogenesis GO Biological Processes -11.5275821 17 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060415 muscle tissue morphogenesis GO Biological Processes -13.8643925 23 More
GO:0060485 mesenchyme development GO Biological Processes -18.0238 46 More
GO:0060537 muscle tissue development GO Biological Processes -18.3336784 54 More
GO:0060956 endocardial cell differentiation GO Biological Processes -6.12313579 5 More
GO:0061061 muscle structure development GO Biological Processes -23.2569142 77 More
GO:0061097 regulation of protein tyrosine kinase activity GO Biological Processes -4.69934335 14 More
GO:0061098 positive regulation of protein tyrosine kinase activity GO Biological Processes -4.90193440 11 More
GO:0061383 trabecula morphogenesis GO Biological Processes -5.83082467 11 More
GO:0061384 heart trabecula morphogenesis GO Biological Processes -4.50023695 8 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0098926 postsynaptic signal transduction GO Biological Processes -3.73790071 8 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0098982 GABA-ergic synapse GO Cellular Components -3.15908473 6 More
GO:0099536 synaptic signaling GO Biological Processes -6.00976162 42 More
GO:1990782 protein tyrosine kinase binding GO Molecular Functions -4.10270724 15 More
GO:2001222 regulation of neuron migration GO Biological Processes -2.05696162 6 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04012 ErbB signaling pathway KEGG Pathway -2.03916116 5 More
Drug-Gene interaction
view
Related drugs: 24 records
Drug name Interaction type Source PMID View
afatinib CIViC 3106837228950338298021582916952428502724 view
alteplase NCI 11679632 view
aspirin NCI 10921413 view
bupivacaine NCI 17294200 view
carboplatin CIViC 23390248 view
cetuximab CIViCPharmGKB 21900593 view
cisplatin CIViC 23390248 view
colchicine NCI 7666195 view
dexamethasone NCI 7599067 view
erlotinib CIViC 29802158 view
gemcitabine CIViC 23390248 view
genistein NCI 17539658 view
isoproterenol NCI 14732742 view
lapatinib CIViC 2569105721840482 view
nicotine NCI 18784291 view
paclitaxel CIViC 23390248 view
panitumumab PharmGKB view
patritumab CIViC 26137564 view
pertuzumab CIViC 29802158 view
progesterone NCI 1252941310597237 view
seribantumab CIViC 20227043 view
tamoxifen NCI 18283314 view
vincristine NCI 17999741 view
wortmannin NCI 10559227 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
cg17457560 hypermethylation epigenomics myocardial infarction[diagnosis] myocardial infarction Rask-Andersen M et al. Hum Mol Genet. 2016
All rights reserved: Soochow University Center for Systems Biology